Synthesis and antitumor activities of 1,2,3-triazines and their benzo- and heterofused derivatives

Eur J Med Chem. 2017 Dec 15:142:74-86. doi: 10.1016/j.ejmech.2017.06.003. Epub 2017 Jun 12.

Abstract

1,2,3-Triazines are a class of biologically active compounds that exhibit a broad spectrum of activities, including antibacterial, antifungal, antiviral, antiproliferative, analgesic and anti-inflammatory properties. This review, which covers the literature from the end of last century to 2016, treats, through a comprehensive, systematic approach, the 1,2,3-triazine and related benzo- and hetero-fused derivatives possessing antitumor activity. Their efficacy, combined with a simple synthesis confers to these molecules a great potential as scaffold for the development of antitumor compounds.

Keywords: 1,2,3-Triazines; Antiproliferative activity; Antitumor activity; Benzo[1,2,3]triazines; Hetero-fused 1,2,3-triazines; Nitrogen heterocycles.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology*
  • Benzene Derivatives / chemical synthesis
  • Benzene Derivatives / chemistry
  • Benzene Derivatives / pharmacology
  • Chemistry Techniques, Synthetic / methods
  • Humans
  • Models, Molecular
  • Neoplasms / drug therapy*
  • Triazines / chemical synthesis
  • Triazines / chemistry*
  • Triazines / pharmacology*

Substances

  • Antineoplastic Agents
  • Benzene Derivatives
  • Triazines